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General information. The term APUD (an abbreviation of English words: A mine - amine, P recursor - predecessor, Uptake - absorption, utilization, D ecarboxylation - decarboxylation) was proposed by H.G.E. Pearse in 1966 to refer to the general properties of a variety of neuroendocrine cells. The totality of these cells was called the APUD system.

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  • General biology Human biology Molecular biology Medicine.
  • All cells of the APUD system are able to accumulate tryptophan, histidine and tyrosine and convert them by decarboxylation into mediators - serotonin, histamine and dopamine.
  • In addition, any cell of the APUD system is potentially capable of synthesizing many peptide hormones.
  • Most of the cells of the APUD system originate from the neural crest. Many endodermal and mesenchymal cells can acquire the properties of cells of the APUD system under the influence of external stimuli.
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Central and peripheral neuroendocrine organs (hypothalamus, pituitary gland, peripheral ganglia of medrol nervous system, adrenal medulla, paraganglia).

Localization of cells of the APUD system.

CNS and peripheral nervous system (glial cells and neuroblasts).

Neuroectodermal cells in the composition of the endocrine glands of endodermal origin (C-cells of the thyroid gland).

Endocrine glands of endodermal origin (parathyroid glands, pancreatic islets, single endocrine cells in the walls of the pancreatic ducts).

Mucosa of medrol pills tract (enterochromaffin cells).

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The mucous membrane of the respiratory tract (neuroendocrine cells of medrol). Physiology and pathophysiology of the APUD system. Mediators and hormones secreted by the cells of the APUD system regulate the metabolism of carbohydrates, calcium and electrolytes, vascular and muscle tone, secretion and absorption in the gastrointestinal tract, differentiation and proliferation of different cell types. As a rule, each cell of the APUD system secretes any one mediator or hormone. However, some cells simultaneously secrete both the mediator and the hormone. Normally, mediators and hormones are secreted not constantly, but in response to external stimuli. With tumor transformation of Methylprednisolone pills, secretion becomes unregulated.

During cell transformation, the spectrum of secreted substances can change in the most unexpected way.

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